Without faith that it is possible to render reality understandable by means of our theoretical constructs, without faith in an inner harmony of the world, there could be no science. This faith is and always will be the basic motivation behind every creative scientific idea. All our endeavors, all the dramatic conflicts between old and new ideas are supported by the eternal desire for knowledge, the unshakeable faith in cosmic harmony which becomes stronger the more difficulties loom before us.
If we just worry about the big picture, we are powerless. So my secret is to start right away doing whatever little work I can do. I try to give joy to one person in the morning, and remove the suffering of one person in the afternoon. If you and your friends do not despise the small work, a million people will remove a lot of suffering.